Cell Culture Media, Supplements, and Reagents
American Research Products Inc Human TGF-alpha PharmaGenie ELISA Kit
Human TGF-alpha PharmaGenie ELISA Kit
Medchemexpress LLC Moclobemide | 71320-77-9 | 99.1% | 50 MG
Moclobemide is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC50 of 6.061 μM for hMAO-A. It up-regulates the proliferation of hippocampal progenitor cells in chronically stressed mice.
- Brain-penetrant and reversible MAO-A inhibitor
- Up-regulates proliferation of hippocampal progenitor cells
- High purity of 99.1%
- Soluble in DMSO at 100 mg/mL
- Powder storage: -20°C for 3 years or 4°C for 2 years
- Storage in solvent: -80°C for 2 years or -20°C for 1 year
Medchemexpress LLC N-(4-mesitylthiazol-2-yl)benzamide | 1001753-24-7 | 99.5% | 322.42 | C19H18N2OS | 25 MG
INH6 is a small-molecule Nek2/Hec1 inhibitor that inactivates Hec1/Nek2 function via protein degradation, leading to chromosome missegregation and cell death. It inhibits HeLa cell growth with an IC50 of 2.4 μM and produces mitotic defects and apoptosis in treated cells.
- Potent Nek2/Hec1 inhibition (IC50 2.4 μM).
- Inactivates Hec1/Nek2 through protein degradation, causing chromosome missegregation.
- Induces mitotic defects and apoptosis in cultured cells (~20% apoptotic cells at 72 h).
- Solid, white to off-white powder; soluble in DMSO (50 mg/mL) and in 10% DMSO/90% corn oil for animal dosing.
- Stable as powder at -20°C (3 years) and 4°C (2 years); in solvent stability varies by temperature.
Medchemexpress LLC 5-(3,3-difluorocyclobutyl)-3-[4-[4-methyl-5-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-3-yl] | 935273-79-3 | MFCD30343842 | 99.2% | 493.47 g/mol | C24H24F5N5O | 25 MG
MK-4101 is a small-molecule Smoothened (SMO) antagonist that inhibits the hedgehog signaling pathway and demonstrates antiproliferative and pro-apoptotic activity in tumor cell models. It is supplied for research use and is characterized by defined molecular properties and high analytical purity.
- Demonstrated antiproliferative and pro-apoptotic activity in cancer cell models.
- High purity (≈99.2%).
- Molecular weight 493.47 g/mol and formula C24H24F5N5O.
- Soluble in DMSO (≥50 mg/mL) for preparation of stock solutions.
- Recommended storage conditions for stability in powder and solution forms.
Medchemexpress LLC SCD1 inhibitor-1 | 1069094-65-0 | 99.9% | 451.54 | 10 MG
SCD1 inhibitor-1 (Compound 48) is an orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1) with an IC50 of 8.8 nM for recombinant human SCD1 enzyme. SCD1 inhibitor-1 can be used in the study of diseases such as diabetes, hepatic steatosis and obesity.
- Orally active and liver-selective inhibitor of stearoyl-CoA desaturase 1 (SCD1).
- IC50 of 8.8 nM for recombinant human SCD1 enzyme.
- Improved effect in high-fat mice models (3-10 mg/kg; oral administration; 43 days), showing improved glucose tolerance in a dose-dependent manner and decreased body weight.
- Improved effect in high-sucrose rat models (1-10 mg/kg; oral administration; single dose), inhibiting SCD1 inhibitory activity in a dose-dependent manner in epididymal adipose tissue and the liver 6 hours after oral administration.
- Selective tissue distribution of liver/eyelid.
Medchemexpress LLC Harmalol hydrochloride | 6028-07-5 | 5 MG
Harmalol hydrochloride is a beta carboline alkaloid found in medicinal plants like *Peganum harmala*. It is the main metabolite of Harmaline and significantly inhibits the dioxin-mediated induction of CYP1A1 at both transcriptional and posttranslational levels. This compound also exhibits antioxidant and hydroxyl radical-scavenging properties.
- Main metabolite of Harmaline.
- Significantly inhibits dioxin-mediated induction of CYP1A1 at transcriptional and posttranslational levels.
- Possesses antioxidant properties.
- Exhibits hydroxyl radical-scavenging properties.
Cayman Chemical ProstaglndIn E2 EthnolamID 1mg
PGE2-EA is an analog of PGE2 with improved water solubility and stability. PGE2-EA acts as an agonist with all four known EP receptor subtypes, but with an affinity that is significantly reduced compared to PGE2. PGE2 ethanolamide is produced by HCA-7 cells treated with AEA.
Bioworld ENDOTOXIN AFFISORBENTPOLY
ENDOTOXIN AFFISORBENT (POLYMYXIN B SEPAROPORE (AGAROSE)): bioWorld's Endotoxin Affisorbentconsists of immobilized polymyxin B on Separopore 6B-CL (6% crosslinked agarose beads). The polymyxins are a family of antibiotics that contain a c...
Sigma Aldrich Fine Chemicals Biosciences Gadoteridol Related Compound B United States Pharmacopeia (USP) Reference Standard | 112188-16-6 | 50MG
Gadoteridol Related Compound B United States Pharmacopeia (USP) Reference Standard | Mol Wt: 500.61 | 112188-16-6 | 50MG
Medchemexpress LLC HY-N0232 5mg Medchemexpress, Psoralidin CAS:18642-23-4 Purity:>98%
Medchemexpress, HY-N0232 5mg Psoralidin CAS:18642-23-4 Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY NSC 102533 10mg
A P2X7 receptor antagonist; inhibits ATP-induced dye uptake in HEK293 cells expressing human purinergic P2X7 receptors (IC50 = 22.4 nM); inhibits common lancehead (B. atrox) venom proteolysis in a concentration-dependent manner; inhibits ATP-induced IL-1ß secretion in human THP-1 monocytes and primary mouse peritoneal macrophages (IC50s = 9.8 and 11.2 nM, respectively); inhibits common lancehead (B. atrox) and jararaca (B. jararaca) venom-induced skin hemorrhage in mice when intradermally administered at 3 mg/kg; inhibits carrageenan-induced paw edema in mice at 0.01 to 1 mg/kg
Medchemexpress LLC Vortioxetine hydrobromide | 960203-27-4 | C18H23BrN2S | 100 MG
Vortioxetine hydrobromide is a multimodal serotonergic agent acting as an antagonist of 5-HT3A and 5-HT7 receptors, and an inhibitor of 5-hydroxytryptamine transporter (SERT). It also functions as a 5-HT1A agonist and a partial 5-HT1B agonist. This compound demonstrates potent inhibition of SERT and exhibits a range of serotonergic activities.
- Antagonist of 5-HT3A and 5-HT7 receptors
- Inhibitor of 5-hydroxytryptamine transporter (SERT)
- Acts as a 5-HT1A agonist and partial 5-HT1B agonist
- Increases cell proliferation and survival
- Stimulates maturation of immature granule cells in the hippocampus
- Does not cause cognitive or psychomotor impairment
- For research use only
Medchemexpress LLC Vortioxetine (Standard) | 508233-74-7 | MFCD22380814 | C18H22N2S | 100 MG
Vortioxetine (Lu AA 21004) is a multimodal serotonergic agent with antagonistic properties at 5-HT3A and 5-HT7 receptors, partial agonist properties at 5-HT1B receptors, and agonistic properties at 5-HT1A receptors. It also acts as a potent inhibitor of the serotonin transporter (SERT). This product is intended for research and analytical applications, and does not cause cognitive or psychomotor impairment.
- Antagonist of 5-HT3A and 5-HT7 receptors
- Inhibitor of serotonin transporter (SERT)
- Agonist of 5-HT1A receptors
- Partial agonist of 5-HT1B receptors
- Increases cell proliferation and survival
- Stimulates maturation of immature granule cells
- Intended for research and analytical applications